Rule of Five

Lipinski's rule of five - rule of thumb that a compound is likely orally active if it violates at most one of: ≤5 hydrogen bond donors; ≤10 hydrogen bond acceptors; molecular mass of ≤500 Da; octanol-water partition coefficient of ≤5. Article “Rule of Five” in German Wikipedia has 24.7 points for quality (as of July 1, 2025). The article contains 3 references and 4 sections.

This article has the best quality in Estonian Wikipedia. However, the most popular language version of this article is English.

Since the creation of article “Rule of Five”, its content was written by 22 registered users of German Wikipedia and edited by 226 registered Wikipedia users in all languages.

The article is cited 8 times in German Wikipedia and cited 172 times in all languages.

The highest Authors Interest rank from 2001:

• Local (German): #36117 in June 2011
• Global: #19170 in September 2005

The highest popularity rank from 2008:

• Local (German): #106571 in February 2018
• Global: #136368 in November 2018

There are 17 language versions for this article in the WikiRank database (of the considered 55 Wikipedia language editions).

The quality and popularity assessment was based on Wikipédia dumps from July 1, 2025 (including revision history and pageviews for previous years).

The table below shows the language versions of the article with the highest quality.

#	Language	Quality grade	Quality score
1	Estonian (et) Lipinski viie reegel		33.1927
2	English (en) Lipinski's rule of five		29.0955
3	German (de) Rule of Five		24.6894
4	Hebrew (he) כלל החמישה של ליפינסקי		23.1856
5	Russian (ru) Правило Липинского		20.9857
6	Dutch (nl) Lipinski's rule of five		20.2959
7	Portuguese (pt) Regra dos 5 de lipinski		18.5415
8	Catalan (ca) Regla del Cinc de Lipinski		15.9398
9	Czech (cs) Lipinského pravidlo		15.4117
10	Spanish (es) Regla de cinco de Lipinski		14.1735

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The following table shows the most popular language versions of the article.

The most popular language versions of the article "Rule of Five" in all the time

#	Language	Popularity award	Relative popularity
1	English (en) Lipinski's rule of five		1 689 243
2	German (de) Rule of Five		140 910
3	Spanish (es) Regla de cinco de Lipinski		79 550
4	Japanese (ja) リピンスキーの法則		76 813
5	Italian (it) Regola di Lipinski		50 770
6	Chinese (zh) 里宾斯基五规则		45 405
7	Russian (ru) Правило Липинского		13 731
8	Dutch (nl) Lipinski's rule of five		10 183
9	Swedish (sv) Lipinskis fem-regel		9 730
10	Ukrainian (uk) Правило п'яти		5 414

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The following table shows the language versions of the article with the highest popularity in the last month.

The most popular language versions of the article "Rule of Five" in June 2025

#	Language	Popularity award	Relative popularity
1	English (en) Lipinski's rule of five		4 810
2	German (de) Rule of Five		396
3	Japanese (ja) リピンスキーの法則		317
4	Chinese (zh) 里宾斯基五规则		236
5	Russian (ru) Правило Липинского		219
6	Spanish (es) Regla de cinco de Lipinski		179
7	Italian (it) Regola di Lipinski		157
8	Portuguese (pt) Regra dos 5 de lipinski		124
9	Dutch (nl) Lipinski's rule of five		78
10	Czech (cs) Lipinského pravidlo		62

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The following table shows the language versions of the article with the highest Authors’ Interest.

Language versions of the article "Rule of Five" with the highest Authors Interest (number of authors). Only registered Wikipedia users were taken into account.

#	Language	AI award	Relative AI
1	English (en) Lipinski's rule of five		93
2	German (de) Rule of Five		22
3	Italian (it) Regola di Lipinski		19
4	Chinese (zh) 里宾斯基五规则		17
5	Japanese (ja) リピンスキーの法則		12
6	Hebrew (he) כלל החמישה של ליפינסקי		10
7	Dutch (nl) Lipinski's rule of five		10
8	Spanish (es) Regla de cinco de Lipinski		7
9	Ukrainian (uk) Правило п'яти		6
10	Arabic (ar) قاعدة ليبينسكي الخماسية		5

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The following table shows the language versions of the article with the highest Authors’ Interest in the last month.

Language versions of the article "Rule of Five" with the highest AI in June 2025

#	Language	AI award	Relative AI
1	Czech (cs) Lipinského pravidlo		1
2	Hebrew (he) כלל החמישה של ליפינסקי		1
3	Arabic (ar) قاعدة ليبينسكي الخماسية		0
4	Catalan (ca) Regla del Cinc de Lipinski		0
5	German (de) Rule of Five		0
6	English (en) Lipinski's rule of five		0
7	Spanish (es) Regla de cinco de Lipinski		0
8	Estonian (et) Lipinski viie reegel		0
9	Italian (it) Regola di Lipinski		0
10	Japanese (ja) リピンスキーの法則		0

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The following table shows the language versions of the article with the highest number of citations.

Language versions of the article "Rule of Five" with the highest Citation Index (CI)

#	Language	CI award	Relative CI
1	English (en) Lipinski's rule of five		72
2	Chinese (zh) 里宾斯基五规则		29
3	Japanese (ja) リピンスキーの法則		15
4	Spanish (es) Regla de cinco de Lipinski		9
5	German (de) Rule of Five		8
6	Italian (it) Regola di Lipinski		8
7	Czech (cs) Lipinského pravidlo		5
8	Estonian (et) Lipinski viie reegel		5
9	Catalan (ca) Regla del Cinc de Lipinski		4
10	Hebrew (he) כלל החמישה של ליפינסקי		3

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#	Language	Value
ar	Arabic قاعدة ليبينسكي الخماسية
ca	Catalan Regla del Cinc de Lipinski
cs	Czech Lipinského pravidlo
de	German Rule of Five
en	English Lipinski's rule of five
es	Spanish Regla de cinco de Lipinski
et	Estonian Lipinski viie reegel
he	Hebrew כלל החמישה של ליפינסקי
it	Italian Regola di Lipinski
ja	Japanese リピンスキーの法則
nl	Dutch Lipinski's rule of five
pt	Portuguese Regra dos 5 de lipinski
ru	Russian Правило Липинского
sl	Slovenian Pravilo Lipinskega
sv	Swedish Lipinskis fem-regel
uk	Ukrainian Правило п'яти
zh	Chinese 里宾斯基五规则

Best Rank

German: #106571 02.2018

Global: #136368 11.2018

Best Rank

German: #36117 06.2011

Global: #19170 09.2005

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The WikiRank project is intended for automatic relative evaluation of the articles in the various language versions of Wikipedia. At the moment the service allows to compare over 44 million Wikipedia articles in 55 languages. Quality scores of articles are based on Wikipedia dumps from July, 2025. When calculating current popularity and AI of articles data from June 2025 was taken into account. For historical values of popularity and AI WikiRank used data from 2001 to 2025... More information